Guaifenesinalso known as guaiphenesin or glyceryl guaiacolate is an expectorant medication sold over the counter and usually taken by mouth to assist the bringing up expectoration of phlegm from the airways in acute respiratory tract infections.
Guaifenesin is used to control cough and is sometimes combined with dextromethorphanan antitussive cough medicinesuch as in Mucinex DM or Robitussin DM. It is also combined with losartan with anesthesia to produce Primatene and Bronkaid tablets for symptomatic relief of asthma, losartan with anesthesia. Side-effects of guaifenesin include nauseavomitingformation of kidney stones diarrhea, and constipation.
Rarely, severe allergic reactions may occur, losartan with anesthesia, including a rash or swelling of the lips or take celebrex and tylenol, which may require urgent medical assistance.
Mild dry mouth or chapped lips may also occur when taking this medication. Drinking a glass of water is recommended with each dose of guaifenesin. Guaifenesin increases the analgesic effect of paracetamol acetaminophen and aspirinincreases the sedative effects of alcohol, tranquilisers, sleep-pills and total anesthetics. Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretions in the losartan with anesthesia and bronchi.
It has been said to aid in the flow of respiratory tract secretions, allowing ciliary movement to carry the loosened secretions upward toward the pharynx, losartan with anesthesia. Guaifenesin has muscle relaxant and anticonvulsant properties and may act as an NMDA receptor antagonist. Similar medicines derived from the guaiac tree were in use as a generic remedy by American indigenous peoples when explorers reached North America in the 16th century.
The Spanish encountered guaiacum wood "when they conquered Santo Domingo; it was soon brought back to Europe, where it acquired an immense reputation in the losartan with anesthesia century as a cure for syphilis and certain other diseases The edition of the Textbook of Pharmacognosy states: The resin is used in chronic gout and rheumatism, whilst the wood is an ingredient in the compound concentrated solution of sarsaparillawhich was losartan with anesthesia much used as an alternative in syphilis.
Although previously deemed "Generally Regarded as Safe" in its original approval, the drug received a New Drug Application for the extended-release version, losartan with anesthesia, which won approval on July 12, Because of this, the Losartan with anesthesia then issued letters to other manufacturers of timed-release guaifenesin to stop marketing their unapproved versions, leaving Adams Respiratory Therapeutics in control of the market.
Guaifenesin is sold as pills or syrups under many brand names. Single-ingredient formulations of guaifenesin are available, and it is also included in many other over-the-counter cough and cold remedy combinations usually in conjunction with dextromethorphanparacetamol soap and skin allergy neomycin sulfateephedrinepseudoephedrineor phenylephrine.
Combination guaifenesin and pseudoephedrine is sold under the brand name Mucinex D, in which "D" refers to the presence of pseudoephedrine, which is a "decongestant".
Guaifenesin is a centrally acting muscle relaxant used routinely in large-animal veterinary surgery. Guaifenesin is used in combination with, for example, losartan with anesthesia, ketamine, since guaifenesin does not produce analgesia nor does it produce unconsciousness. The guaifenesin protocol was studied as a method to treat fibromyalgia ; a one-year double-blinded study found that the treatment performs no better than placebo. Guaifenesin was studied as a method to improve the possibility of conceptionby thinning and increasing the stretchability improved spinnbarkeit of the cervical mucusduring the few days before ovulation, thus facilitating sperm penetration.
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