Plasma curves were fitted according to a one compartment open model. Some impairment of demethylation to 3-methylxanthine was observed in two subjects, however the percentage of theophylline and its major metabolites excreted in urine was constant for all the four doses. National Center for Biotechnology InformationU. Br J Clin Pharmacol. This article has been cited by other articles in PMC.
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