All of these patients had concomitant organic brain dysfunction, ranging from minimal propranolol anger outbursts dysfunction to severe, uncontrolled seizures. All patients had prior unsuccessful medication treatment, consisting of trials on stimulants, neuroleptics, anticonvulsants, or combinations of these.
The majority of patients also had prior psychotherapeutic intervention, all without success. These data point to the merits of a controlled prospective study of the use of propranolol in treating neurologically impaired children and adolescents with uncontrolled rage outbursts. The authors are grateful to Dr.
Donald Ross and Mrs. Henny Wolland for statistical guidance, to Dr. Arnold Gold and Dr. Richard Masland for clinical, advice, and Dr. Rachel Gittelman, and Dr. Donald Klein for their editorial suggestions, propranolol anger outbursts. We are also grateful for financial support provided by the Wodecroft Foundation. Psychiatric Institute MH This paper was presented at the annual meeting of the American Academy of Child Psychiatry, Chicago.