Gentamicintetracycline and deafness, sold under brand names Garamycin among others, is an antibiotic used to treat several types of bacterial infections. Gentamicin can cause inner ear problems and kidney problems. Gentamicin was discovered in Active against a wide range of bacterial infections, mostly Gram-negative bacteria including PseudomonasProteusEscherichia coliKlebsiella pneumoniaeEnterobacter aerogenesSerratiaand the Gram-positive Staphylococcus.
There is insufficient evidence to support gentamicin as the first line treatment of Neisseria gonorrhea infection. Some Enterobacteriaceaetetracycline and deafness, Pseudomonas spp.
Adverse effects of gentamicin can range from less severe reactions such as nausea and vomiting to more severe reactions such as: Nephrotoxicity and ototoxicity are thought to be dose related with higher doses causing greater chance of toxicity. Factors that increase risk of nephrotoxicity include: Kidney dysfunction is monitored by measuring creatinine in the blood, electrolyte levels, low urine outputfoamy urineand concentrations of other chemicals in the blood.
First, damage of the inner ear hair cells can result in irreversible hearing loss. Second, tetracycline and deafness, damage to inner ear vestibular apparatus can lead to balance problems.
Factors that increase risk of inner ear damage include: Gentamicin is a bactericidal antibiotic that works by irreversibly binding the 30S subunit of the bacterial ribosome, interrupting protein synthesis, tetracycline and deafness.
This mechanism of action is similar to other aminoglycosides, tetracycline and deafness. Gentamicin is composed of a number of related gentamicin components and rabeprazole and alcohol which have varying degrees of antimicrobial potency. Because of this lot-to-lot variability, it can be difficult to study various properties of gentamicin including pharmacokinetics and microorganism susceptibility if there is an unknown combination of chemically related but different compounds.
Gentamicin should not be used if a person has a history of hypersensitivity such as anaphylaxis shock or other serious toxic reaction to gentamicin or any other aminoglycosides. Gentamicin is not recommended in pregnancy unless the benefits outweigh the risks for the mother.
Gentamicin can cross the placenta and several reports of irreversible bilateral congenital deafness in children have been seen. Intramuscular injection of gentamicin in mothers can cause muscle weakness tetracycline and deafness the newborn. The safety and efficacy for gentamicin in nursing mothers has not been established, tetracycline and deafness.
Detectable gentamicin levels are found in human breast milk and in nursing babies. Renal function should be assessed before beginning therapy and during in tetracycline and deafness due to a decline in glomerular filtration rate. This population can have longer than usual gentamicin levels in the body. Use cautiously in persons with renalauditoryvestibularor neuromuscular dysfunction.
Gentamicin may not be appropriate to use in children, including newborns and infants. Studies have shown higher serum levels and a longer half-life in this population. Check renal function periodically during therapy. Hypocalcemiahypokalemiaand muscle weakness have been reported after gentamicin injection. Gentamicin is produced by the fermentation of Micromonospora purpurea.
It was discovered in by Weinstein, Wagman et al. It was initially used as a topical treatment for burns at the Atlanta and San Antonio burn units and was introduced into IV usage in It remains a mainstay for use in sepsis.
It is synthesized by Micromonosporaa genus of Gram-positive bacteria widely present in the environment water and soil. Gentamicin is also used in molecular biology research as an antibacterial agent in tissue and cell culture, to prevent contamination of sterile cultures.
Gentamicin is one of the few heat-stable antibiotics that remain active even after autoclavingwhich makes it particularly useful in the preparation of some microbiological growth media.
From Wikipedia, the free encyclopedia. D Evidence of risk. Archived from the original on Retrieved Aug 15, Clinical Ocular Pharmacology s ed. Archived from the original on 6 September Retrieved 15 August Handbook of antibiotic discovery and development ed. Archived PDF from the original on tetracycline and deafness December Retrieved 8 December International Drug Price Indicator Guide. Archived from the original on 22 January Archived from the original PDF on 4 March Retrieved 2 November Archived PDF from the original on 12 April Rapid Review Pathology 3rd ed.
Archived from the original PDF on 20 February Retrieved 15 May Antimicrobial Agents and Chemotherapy. Antibiotics and chemotherapeutics for dermatological use D Demeclocycline Chlortetracycline Oxytetracycline Tetracycline.
Neomycin Gentamicin Amikacin Quinolones: Fusidic acid Bacitracin Tyrothricin Mupirocin, tetracycline and deafness. Chloramphenicol Azidamfenicol Thiamphenicol Florfenicol. Drugs used for diseases tetracycline and deafness the ear S Betamethasone Dexamethasone Fluocinolone acetonide Hydrocortisone Prednisolone.
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