Having too little thyroid hormone in the blood—even in the low-normal range—raises the risk of developing type 2 diabetes, especially in people with prediabetes, a new study in nearly 8, people finds. Adults in the lowest third of thyroid function levels had a 1. Dutch researchers used a cohort of adults without diabetes at baseline, ages 45 and older, and found those with higher thyroid-stimulating thyroid and diabetes had a 1.
Chaker presented the results at ENDO Thyroid hormone is important for strattera and liver failure, and thus important in controlling weight and cholesterol metabolism. Therefore, Dr Chaker thyroid and diabetes her team hypothesized that thyroid hormone could also be important in the development of type 2 diabetes.
To test their hypothesis, the research team evaluated thyroid function, incidence of diabetes, and progression from prediabetes to diabetes. Chaker and colleagues selected 8, thyroid and diabetes, participants from the Rotterdam Thyroid and diabetes, a population-based study of adults aged 45 or older that reflects the general population in the Netherlands, thyroid and diabetes. No thyroid and diabetes had diabetes at baseline, thyroid and diabetes.
All participants were tested for blood sugar and thyroid function, and re-examined every 2 to 3 years to check for the development of type 2 diabetes. Over an average follow-up of nearly eight years, 1, participants developed prediabetes and developed diabetes.
Risk for progression from prediabetes to diabetes was 1. The researchers found it surprising that even people whose thyroid function was in the low-normal range had an increased risk of diabetes.
From the results, the researchers suggested that we should consider screening people with prediabetes for low thyroid function. They also learned that hypothyroidism is associated with increased risk for diabetes and subclinical hypothyroidism appears to increase this risk only thyroid and diabetes statin use, according to research published in Diabetes Care.
Naomi Gronich, MD, from the Israel Institute of Technology in Haifa, and colleagues examined risk factors for the development of statin-associated diabetes in a two-phase study. Risk factors were identified in a high-throughput in silico processing phase. In the second phase, the most prominent risk factor identified was confirmed in an observational cohort study at the largest healthcare organization in Israel.
Overall, 39, statin nonusers were propensity score matched with 20, highly compliant statin initiators in to ; patients were followed through In a multivariable model, hypothyroidism and subclinical hypothyroidism correlated with increased risk for diabetes rate ratios, 1. The correlation between hypothyroidism and increased diabetes risk was seen for statin users and nonusers, regardless of statin use rate ratios, 2.
Subclinical hypothyroidism also correlated with increased diabetes risk only for statin users rate ratios, 1. There was no increased diabetes risk for patients with hypothyroidism treated with thyroid hormone replacement therapy.
Thyroid Function and type 2 diabetes risk: Gronich N et al. Share Facebook Twitter LinkedIn. Previous Can Fingerprints Predict Diabetes? Next Connection Between Nicotine and Diabetes.