Sign up for a free Medical News Today account to customize your medical and health news experiences, vitamin c and chemotherapy.
A new study suggests giving some cancer patients high doses of vitamin C intravenously - as opposed to orally - alongside conventional chemotherapy, may help kill cancer cells and also reduce some of its toxic side effects. Reporting their findings in Science Translational Medicineresearchers from the University of Kansas KU Medical Center describe how they tested the approach in cells, animals and humans. They found giving infused vitamin C together with carboplatin and paclitaxel - two conventional chemotherapy drugs - stopped ovarian cancer in the lab and also vitamin c and chemotherapy toxic side effects of chemotherapy in ovarian cancer patients.
Since the s, ascorbate - or vitamin C - has been used as an alternative therapy for cancer. It has an "outstanding safety profile," write the researchers, who also note there were anecdotal reports that it was effective if given intravenously. Vitamin c and chemotherapy, although complementary and alternative therapy doctors continued to use it to combat cancer, conventional oncologists abandoned its use after clinical trials of orally administered vitamin C found it was ineffective against cancer.
Now, more recent studies have resurrected the possibility that intravenous vitamin C may be worth looking at again as a possible anti-cancer therapy, so the KU researchers decided to investigate.
And indeed, what they found was that vitamin C can be effective against cancer when given intravenously, as senior author Qi Chen, assistant professor in the Department of Pharmacology, Toxicology and Therapeutics at the KU Medical Center, explains:.
For their clinical trial, the researchers vitamin c and chemotherapy 27 patients who had just been diagnosed with stage 3 or stage 4 ovarian cancer. They all underwent conventional chemotherapy with paclitaxel or carboplatin, but some also received high doses of vitamin C intravenously.
They were then followed for 5 years. The researchers found that, compared with the patients who did not receive vitamin C in addition to conventional chemotherapy, the toxic effects of the therapy tended to be less in the patients given vitamin C. In another experiment, the researchers vitamin c and chemotherapy vitamin C killed cancer cells in mice with ovarian cancer, but only at concentrations that can be achieved if given intravenously.
When they looked at what was happening at the molecular level, they found vitamin C in the fluid surrounding tumor cells acts as a "pro-oxidant," spurring formation of hydrogen peroxide, which kills cancer cells. On further investigation of this path, the researchers found a number of mechanisms through which, acting as a pro-oxidant, vitamin C induced cell death in ovarian cancer cells, including promoting damage to their DNA, without affecting healthy tissue.
Taken together, our data provide strong evidence to justify larger and robust clinical trials to definitively examine the benefit of adding vitamin C to conventional chemotherapy. However, it may not be easy to find funding for large clinical trials of intravenous vitamin C. Pharmaceutical companies, for example, are unlikely valproic acid and msds be interested because with vitamin C being a natural substance, they would not be able to patent it.
Meanwhile, Medical News Today reported a study that suggests athletes should avoid supplementing with vitamin C and vitamin E as it may hamper their endurance training. MNT is the registered trade mark of Healthline Media. Any medical information published on this website is not intended as a substitute for informed medical advice and you should vitamin c and chemotherapy take any action before consulting with a healthcare professional.
Privacy Terms Ad policy Careers. This page was printed from: Get the most out of Medical News Today. Subscribe to our Newsletter to recieve: Professionally-verified articles Daily or weekly updates Content custom-tailored to your needs Create an account.
Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Register for a free account Sign up for a free Medical News Today account to customize your medical and health news experiences.
Latest news Existing antibiotic could help treat melanoma. Drug resistance is a significant problem when treating melanoma. A new study concludes that an old antibiotic might offer new hope, vitamin c and chemotherapy.
A new study examines the brains of people with seasonal affective disorder to examine why some people do not develop depression despite being at risk.
What makes whole grains so healthful? A new study lifts the lid. Drinking water lowers the risk of bladder infections.
Vitamin c and chemotherapy have recently conducted a new study into bladder infections. They now suggest that we ought to drink plenty of water to keep them at bay. Why I now agree with vaccination. In this article, I explore why I disagree with her decision, and why I chose to get vaccinated as an adult.
Can you get cancer on the tonsils? New cancer vaccine may tackle HER2-positive tumors Can aspirin help treat cancer? Subscribe Your privacy is important to us.