Bausch Health Companies Inc. May increase after several weeks to max mg once daily. Renal or mild hepatic impairment: During or within 14 days of discontinuing MAOIs. Concomitant linezolid or IV methylene blue. Abrupt withdrawal of alcohol, benzodiazepines, barbiturates, or antiepileptics. Other forms of bupropion eg, Zyban. Not for treating bipolar depression wellbutrin xl and mania for smoking cessation. Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor all patients for clinical worsening or unusual behavioral changes.
Monitor for neuropsychiatric adverse events eg, behavioral changes, agitation, depression, suicidal ideation ; evaluate and consider treatment continuation under closer monitoring, or discontinuation if occur. Risk of seizures; discontinue if seizure occurs: Monitor BP before initiating and periodically during treatment.
Hepatic or renal impairment monitor closely. Maintain at lowest effective dose. Do not start with concomitant linezolid or IV methylene blue; if treatment necessary, discontinue bupropion before starting.
Monitor for 2 weeks or until 24hrs after last dose of linezolid or IV methylene blue, whichever comes first. Levodopa, amantadine may increase CNS toxicity. Caution with drugs that lower seizure threshold eg, theophylline, antidiabetics, anorectics, CNS stimulants, systemic steroids, tricyclic antidepressants, antipsychotics or factors that lower seizure threshold eg, opiate or cocaine addiction, wellbutrin xl and mania use of alcohol or sedatives.
Caution with CYP2B6 inducers eg, ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, phenytointamoxifen; consider dose increase. May antagonize digoxin; monitor. Dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, wellbutrin xl and mania, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, rash rarely may be serious, eg, wellbutrin xl and mania, erythema multiforme, Stevens-Johnson syndromeheadache, blurred vision, tachycardia; hypertension.
Generic Name and Formulations: Bupropion HCl mg, mg; ext-rel tabs. Major depressive disorder MDD. Seasonal affective disorder SAD. Suicidal thoughts and behaviors. XL tabs mg—30, 90; mg—30; SR tabs—60; Tabs—contact supplier.