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Our rapidly increasing knowledge about tumors of the brain and spine has rendered these tumors more treatable than ever before. This book, like the others in this series, highlights integrated care and focuses on treating the patient through the entire spectrum of the disease. The thorough, practical volume includes more than 70 yahooanswers brain and spine cancer and 30 tables and is an essential clinical guide for oncologists, surgeons and other health care providers involved in the care of patients with central nervous system tumors.
Chapter 5 Low-grade Gliomas: Chapter 9 Malignant Gliomas: Gilbert and Anita Mahajan. Although the annual incidence of intrinsic tumors of the central nervous system CNS — about 17, to 20, in the United States—is much lower than that of more common cancers arising in the lung, breast, or other sites, CNS tumors are prominent in oncology for several reasons.
First, yahooanswers brain and spine cancer, they attack the very structure of our personhood and in so doing, create fear and functional deficits as profound as they are disturbing to patients and their families alike.
Second, CNS tumors can be difficult to cure when they are infiltrative or located in places that are difficult to access surgically without putting patients at some risk. Third, since tumors originating in any organ system can secondarily affect the brain or spine, much crossover exists between neuro-oncology and general oncology.
And finally, CNS tumors are prominent in oncology because of the great strides being made in our understanding of these tumors on a molecular and genetic level and because treatments can now be based on hitherto unrecognized genetic alterations, advances that go hand in hand with similar knowledge being gathered in all the subspecialties of oncology.
Because of our rapidly increasing knowledge about tumors of the yahooanswers brain and spine cancer and spinethese tumors are becoming more treatable—either for palliation or for cure—than ever before.
The effects of environmental exposures on tumor formation are coming more into focus, and epidemiologic knowledge is now linking nicely with molecular genetic alterations derived from kindreds susceptible to brain tumor formation. Such alterations have been correlated with a progression from benign to malignant forms of several tumor types, most notably the astrocytoma; and although an initiating genetic mutation cannot yet be traced for most tumors, molecular genetics is now being used in neuropathologic diagnoses to supplement more traditional histologic approaches.
Diagnostic tools such as magnetic resonance imaging continue to develop and have become quite sensitive, albeit less than perfectly specific, in revealing Synthroid and cytomel versus armour tumors at earlier and earlier stages. Surgical procedures too are advancing through a combination of more complex technologies and the development of a cadre of neurosurgeons specialized in the nuances of tumor care.
For example, oral temozolomide is better tolerated by patients than predecessor intravenous chemotherapeutic agents and is more effective in patients with epigenetic silencing of the MGMT gene associated with DNA repair. This agent has become the standard of care for patients with anaplastic or malignant astrocytomas after resection and irradiation. The first of these was published in and was devoted to breast cancer.
This book, like the others, highlights integrated care and focuses on treating the patient through the entire spectrum of a disease. And we thank you, the reader, for your interest in this most intricate and fascinating corner of oncology in which we practice our art and our science. It is frequently stated that progress in the management of tumors of the brain and spine has not occurred in the past 25 years.
Such statements seriously underestimate and misrepresent progress in managing various central nervous system tumors, the tremendous technologic enhancements that have revolutionized the imaging of the tumors and the host organ, the tysabri and arthritis side effects of surgical adjuncts such as computerized imaging guidance and functional mapping of the brain and its tracts that are routinely used in the modern neurosurgical operating room, and the highly conformal delivery of radiation to the tumor mass with remarkable sparing of the surrounding nervous tissue.
Underlying these technologic improvements are the changes in philosophy that have resulted in a true yahooanswers brain and spine cancer approach. Equally significant is the molecular revolution that is identifying key markers behind the genesis of brain tumors, their proliferation, and their resistance to therapy, yahooanswers brain and spine cancer.
These molecular discoveries have ushered in the era of molecular targeted therapy, as first demonstrated by the extraordinary success story in chronic myelogenous leukemia of imatinib Gleevec. The rational combination of targeted agents will revolutionize the way chemotherapy is given, yahooanswers brain and spine cancer, either alone or in conjunction with radiotherapy.
Their expertise and commitment to their patients is evident throughout. Tumors of the Brain and Spine. Edited by Franco DeMonte, M. Table of contents Foreword Raymond Sawaya and W.
McCutcheon Chapter 5 Low-grade Gliomas: Gilbert Chapter 9 Malignant Gliomas: Our Labs Learn more about our faculty and the research taking place in our labs. Conferences View conferences available for continuing medical education credit. Subscribe Get the latest information on our cancer breakthroughs.